![]() The components required to design such a diet should focus on the specific ancestry of each population around the world and the convenience of consuming traditional ethnic food. ![]() Here, we provide the rationale for an intervention strategy for the prevention and management of obesity-related diseases such as non-alcoholic steatohepatitis based on a regionalized genome-based diet. International guidelines and intervention strategies may not be adequate for all populations worldwide because they do not consider disparities in genetic and environmental factors, and thus there is a need for differential prevention and management strategies. At present, the unbalanced diet composition of the Mexicans has led the country to a 70% prevalence rate of overweightness and obesity due to substantial changes in food habits, among other factors. Such interactions may have promoted the positive selection of variants adapted to regional food sources. However, certain high allelic frequencies of several nutrient-related polymorphisms may have been achieved by past gene-nutrient interactions. In Latin America, most countries, including Mexico, have a heterogeneous admixture genome with Amerindian, European and African ancestries. Obesity and nonalcoholic steatohepatitis are increasing in westernized countries, regardless of their geographic location.
0 Comments
Leave a Reply. |